Tgs1 Gene Summary [Mouse]
Predicted to enable RNA cap trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgs1 |
| Official Name | trimethylguanosine synthase 1 [Source:MGI Symbol;Acc:MGI:2151797] |
| Ensembl ID | ENSMUSG00000028233 |
| Bio databases IDs | |
| Aliases | trimethylguanosine synthase 1 |
| Synonyms | D4Ertd800e, KW2, NCOA6IP, PIMT, PIPMT, trimethylguanosine synthase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
Pathways
Biological processes and signaling networks where the Tgs1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- impaired glucose tolerance
- hyperglycemia
- hypoinsulinemia
role in cell
- expression in
- apoptosis
- processing in
- capping in
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoprotein complex biogenesis
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- Cajal body
- cytosol
- nucleolus
- small nuclear ribonucleoprotein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA methyltransferase activity
- RNA trimethylguanosine synthase activity
- protein binding