Sun1 Gene Summary [Mouse]
Enables lamin binding activity. Involved in centrosome localization; meiotic attachment of telomere to nuclear envelope; and nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration. Acts upstream of or within homologous chromosome pairing at meiosis. Located in chromosome, telomeric region; cytoplasm; and nuclear inner membrane. Is expressed in epidermis; intercostal muscle; spermatocyte; and spermatozoon. Orthologous to human SUN1 (Sad1 and UNC84 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sun1 |
| Official Name | Sad1 and UNC84 domain containing 1 [Source:MGI Symbol;Acc:MGI:1924303] |
| Ensembl ID | ENSMUSG00000036817 |
| Bio databases IDs | |
| Aliases | Sad1 and UNC84 domain containing 1 |
| Synonyms | 4632417G13Rik, 5730434D03RIK, mKIAA0810, Sad1 and UNC84 domain containing 1, SAD1 UNC-84 domain protein1, UNC84A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sun1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoplasmic domain
- coiled-coil domain 1 of SUN domain-containing proteins
- Sad1 / UNC-like C-terminal
- protein binding activity, bridging
- lamin binding
- protein binding
- SUN2 helix-turn-helix domain
- endoplasmic reticulum lumenal domain
- identical protein binding
- lumenal domain
- Mitochondrial RNA binding protein MRP
- zinc finger domain
- basic domain
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- lordokyphosis
- atrial fibrillation
- azoospermia
- insomnia
- ataxia
- cyanosis
- absent pinna reflex
role in cell
- quantity
- apoptosis
- morphology
- activation in
- damage in
- number
- clustering
- meiosis
- abnormal morphology
- cellular disorientation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cellular membrane
- cytosol
- chromosome
- nuclear pores
- inner nuclear membrane
- nuclear envelope
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sun1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
- ossification
- attachment of telomeric heterochromatin to nuclear envelope
- spermatogenesis
- nuclear matrix anchoring at nuclear membrane
- synapsis
- response to mechanical stimulus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- chromosome, telomeric region
- nuclear membrane
- nuclear inner membrane
- cytoplasm
- intracellular membrane-bounded organelle
- SUN-KASH complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein anchor
- lamin binding