Clca2 Gene Summary [Mouse]
This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Clca2 |
| Official Name | chloride channel accessory 2 [Source:MGI Symbol;Acc:MGI:2139758] |
| Ensembl ID | ENSMUSG00000036960 |
| Bio databases IDs | |
| Aliases | chloride channel accessory 2 |
| Synonyms | 4732440A06, AI586120, CACC, CACC3, chloride channel accessory 2, Clca5, CLCRG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clca2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel N terminal
- calcium-activated chloride channel protein 1
- von Willebrand factor (vWF) type A domain
- vWFA
- chloride channel
- ligand-gated ion channel
- von Willebrand factor type A domain
- ion channel
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- neoplasia
- hallux valgus
- psoriasis
role in cell
- expression in
- adhesion
- proliferation
- phosphorylation in
- invasion by
- apoptosis
- survival
- invasion
- migration
- cell focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clca2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- proteolysis
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- nuclear membrane
- anchoring junction
- cell junction
- cytosol
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- intracellular calcium activated chloride channel activity
- metal ion binding
- chloride channel activity
- metalloendopeptidase activity