Ndc1 Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within homologous chromosome pairing at meiosis and spermatogenesis. Located in cytoplasm. Part of nuclear pore. Is expressed in several structures, including forelimb bud; gonad; lung; and spleen. Orthologous to human NDC1 (NDC1 transmembrane nucleoporin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndc1 |
| Official Name | NDC1 transmembrane nucleoporin [Source:MGI Symbol;Acc:MGI:1920037] |
| Ensembl ID | ENSMUSG00000028614 |
| Bio databases IDs | |
| Aliases | NDC1 transmembrane nucleoporin |
| Synonyms | 2810475A17RIK, AI450313, NDC1 transmembrane nucleoporin, NET3, sks, TMEM48 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- Nucleoporin protein Ndc1-Nup
Pathways
Biological processes and signaling networks where the Ndc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- nuclear pores
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear pore localization
- nucleocytoplasmic transport
- nuclear pore organization
- spermatogenesis
- protein transport
- nuclear pore complex assembly
- synapsis
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- cytoplasm
- membrane
- actin cytoskeleton
- NDC1 complex
- plasma membrane
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- structural constituent of nuclear pore
- protein binding, bridging