Trim3 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in protein ubiquitination. Located in cytoplasm. Is expressed in several structures, including adrenal gland; cardiovascular system; genitourinary system; gut gland; and nervous system. Orthologous to human TRIM3 (tripartite motif containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim3 |
| Official Name | tripartite motif-containing 3 [Source:MGI Symbol;Acc:MGI:1860040] |
| Ensembl ID | ENSMUSG00000036989 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 3 |
| Synonyms | BERP, BERP1, HAC1, RNF22, RNF97, tripartite motif-containing 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Filamin/ABP280 repeat
- B-Box C-terminal domain
- coiled-coil domain
- enzyme
- NHL repeat unit of beta-propeller proteins
- identical protein binding
- myosin-binding domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- B-box zinc finger
- Filamin-type immunoglobulin domains
- zinc-RING finger domain
- dimerization domain
- beta propeller
- RING B-box domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- Ring finger domain
- protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- NHL repeat
- ubiquitin-protein transferase activity
- Apolipoprotein A1/A4/E domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- metastasis
- pneumonitis
role in cell
- proliferation
- expression in
- quantity
- outgrowth
- activation in
- binding in
- cell spreading
- signaling
- invasion by
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cell periphery
- postsynaptic region
- cell cortex
- Golgi Apparatus
- synapse
- early endosomes
- perikaryon
- dendrites
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 3 signaling pathway
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- protein transport
- nervous system development
- protein K63-linked ubiquitination
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- dendrite
- early endosome
- cytoplasm
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding
- translation repressor activity