Lrg1 Gene Summary [Mouse]
Enables transforming growth factor beta receptor binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of endothelial cell proliferation; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in pancreas mesenchyme. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrg1 |
| Official Name | leucine-rich alpha-2-glycoprotein 1 [Source:MGI Symbol;Acc:MGI:1924155] |
| Ensembl ID | ENSMUSG00000037095 |
| Bio databases IDs | |
| Aliases | leucine-rich alpha-2-glycoprotein 1 |
| Synonyms | 1300008B03Rik, 2310031E04Rik, HMFT1766, Leucine-rich alpha-2-glycoprotein, leucine-rich alpha-2-glycoprotein 1, Leucine-rich α-2-glycoprotein, leucine-rich α-2-glycoprotein 1, LRG, Lrgh, Lrhg |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- punt binding
- protein phosphatase 1 regulatory subunit 42
- transforming growth factor-beta receptor binding
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- septic shock
- organismal death
- prostate cancer
- liver cancer
- progressive supranuclear palsy
- coronary artery disease
- Alzheimer disease
- Parkinson disease with dementia
- atherosclerosis
role in cell
- proliferation
- phosphorylation in
- invasion by
- migration
- polarization
- M1 polarization
- differentiation
- morphology
- epithelial-mesenchymal transition
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- secretory granule lumen
- ficolin-1-rich granule lumen
- organelle lumens
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of epithelial to mesenchymal transition
- brown fat cell differentiation
- positive regulation of keratinocyte proliferation
- response to bacterium
- positive regulation of epithelial cell proliferation involved in wound healing
- positive regulation of endothelial cell proliferation
- wound healing, spreading of epidermal cells
- positive regulation of angiogenesis
- positive regulation of transforming growth factor beta receptor signaling pathway
- keratinocyte migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- intracellular membrane-bounded organelle
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- type II transforming growth factor beta receptor binding
- type I transforming growth factor beta receptor binding