Tmprss13 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within establishment of skin barrier. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and immune system. Orthologous to human TMPRSS13 (transmembrane serine protease 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmprss13 |
| Official Name | transmembrane protease, serine 13 [Source:MGI Symbol;Acc:MGI:2682935] |
| Ensembl ID | ENSMUSG00000037129 |
| Bio databases IDs | |
| Aliases | transmembrane protease, serine 13 |
| Synonyms | Mosaic serine protease, MSP, RGD1310872, TMPRSS11, Tpmrss13, transmembrane protease, serine 13, transmembrane serine protease 13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmprss13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- peptidase
- Domain of unknown function (DUF1986)
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
regulates
- PRSS8
- S
- pGlu-Arg-Thr-Lys-Arg-AMC
role in cell
- proliferation
- apoptosis
- invasion by
- activation in
- molecular cleavage in
- fusion
- paclitaxel sensitivity
- spreading in
- carboplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmprss13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- blood microparticle
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity