Ptprk Gene Summary [Mouse]
Enables protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in several cellular components, including dendrite; neuronal cell body; and photoreceptor outer segment. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprk |
| Official Name | protein tyrosine phosphatase, receptor type, K [Source:MGI Symbol;Acc:MGI:103310] |
| Ensembl ID | ENSMUSG00000019889 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, K |
| Synonyms | protein tyrosine phosphatase receptor type K, protein tyrosine phosphatase, receptor type, K, PTPk, PTP-κ, Rptpk, R-PTP-kappa, R-PTP-κ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- beta-catenin binding
- catalytic domain
- immunoglobulin domain
- Protein tyrosine phosphatase, catalytic domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- PTP_DSP_cys
- phosphatase domain
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- gamma-catenin binding
- FN3
- Immunoglobulin like
- phosphatase
- active site
- MAM domain, meprin/A5/mu
Pathways
Biological processes and signaling networks where the Ptprk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- allergic rhinitis
- celiac disease
- allergy
- hearing loss
- schizophrenia
- generalized epilepsy
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- phosphorylation in
- survival
- growth
- proliferation
- adhesion
- migration
- assembly
- cell cycle progression
- morphogenesis
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- Nucleus
- intercellular junctions
- photoreceptor outer segments
- anchoring junction
- cell membrane leading edge
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- signal transduction
- negative regulation of cell proliferation
- protein dephosphorylation
- transforming growth factor beta receptor signaling pathway
- negative regulation of cell cycle
- cell adhesion
- negative regulation of keratinocyte proliferation
- negative regulation of transcription, DNA-dependent
- cellular response to UV
- focal adhesion assembly
- cell migration
- cellular response to reactive oxygen species
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cell-cell junction
- intracellular membrane-bounded organelle
- membrane
- cell junction
- leading edge membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- gamma-catenin binding
- protein binding
- protein tyrosine phosphatase activity
- beta-catenin binding
- transmembrane receptor protein tyrosine phosphatase activity