Tmprss2 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and respiratory system. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmprss2 |
| Official Name | transmembrane protease, serine 2 [Source:MGI Symbol;Acc:MGI:1354381] |
| Ensembl ID | ENSMUSG00000000385 |
| Bio databases IDs | |
| Aliases | transmembrane protease, serine 2 |
| Synonyms | D16Ertd61e, PP9284, PRSS10, transmembrane protease, serine 2, Transmembrane serine protease 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmprss2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- LDLa
- Domain of unknown function (DUF1986)
- protein binding
- zDHHC ankyrin repeat binding domain
- Scavenger receptor Cys-rich
Pathways
Biological processes and signaling networks where the Tmprss2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- optic atrophy
- liver cancer
- epithelial cancer
- COVID-19
- prostate cancer
- prostatic carcinoma
- hepatocellular carcinoma
- prostatic intraepithelial neoplasia
- renal clear cell adenocarcinoma
- tumorigenesis
role in cell
- expression in
- activation in
- binding in
- replication in
- molecular cleavage in
- viral entry
- fusion
- entrance
- spreading in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- tetraspanin-enriched microdomain
- Cytoplasm
- Extracellular Space
- apical compartment
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmprss2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- positive regulation of viral entry into host cell
- protein autoprocessing
- viral protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type peptidase activity
- serine-type endopeptidase activity