Spry1 Gene Summary [Mouse]
Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within several processes, including bud elongation involved in lung branching; kidney development; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including branchial arch; embryo ectoderm; integumental system; limb; and sensory organ. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spry1 |
| Official Name | sprouty RTK signaling antagonist 1 [Source:MGI Symbol;Acc:MGI:1345139] |
| Ensembl ID | ENSMUSG00000037211 |
| Bio databases IDs | |
| Aliases | sprouty RTK signaling antagonist 1 |
| Synonyms | hSPRY1, Sproudtyl, SPROUTY 1, sprouty RTK signaling antagonist 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spry1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Sprouty protein (Spry)
Pathways
Biological processes and signaling networks where the Spry1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplastic cell transformation
- diabetic nephropathy
- prostatic intraepithelial neoplasia
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- hereditary disorder
- dilation of ureter
role in cell
- stimulation
- proliferation
- phosphorylation in
- expression in
- binding in
- activation in
- activation
- production in
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- cytosol
- membrane ruffles
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spry1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of MAP kinase activity
- negative regulation of cell proliferation
- bud elongation involved in lung branching
- organ development
- epithelial to mesenchymal transition involved in cardiac fibroblast development
- ERK1 and ERK2 cascade
- establishment of mitotic spindle orientation
- negative regulation of nerve growth factor receptor signaling pathway
- negative regulation of Ras protein signal transduction
- negative regulation of epithelial to mesenchymal transition
- metanephros development
- ureteric bud development
- negative regulation of ERK1 and ERK2 cascade
- organ induction
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding