Chst7 Gene Summary [Mouse]
Enables chondroitin 6-sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Is active in Golgi apparatus. Is expressed in several structures, including brain; endocrine gland; immune system; respiratory system; and tail unsegmented mesenchyme. Orthologous to human CHST7 (carbohydrate sulfotransferase 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chst7 |
| Official Name | carbohydrate (N-acetylglucosamino) sulfotransferase 7 [Source:MGI Symbol;Acc:MGI:1891767] |
| Ensembl ID | ENSMUSG00000037347 |
| Bio databases IDs | |
| Aliases | carbohydrate (N-acetylglucosamino) sulfotransferase 7 |
| Synonyms | 2600013M07Rik, C6ST-2, carbohydrate sulfotransferase 7, carbohydrate sulphotransferase 7, glcNAc6ST-4, Gn6st-4, GST-5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chst7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- chondroitin 6-sulfotransferase
- N-acetylglucosamine-6-O-sulfotransferase
- enzyme
Pathways
Biological processes and signaling networks where the Chst7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- diabetic nephropathy
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
regulates
- benzyl 2-acetamido-2-deoxy-beta-d-glucopyranoside
- Glycam1
- IgG
- chondroitin
- N-acetylglucosamine
- keratan sulfate
- polysaccharide
- N-acetylglucosamine beta1-O-(CH2)7-CH3
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chst7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- polysaccharide metabolic process
- sulfur compound metabolic process
- N-acetylglucosamine metabolic process
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetylglucosamine 6-O-sulfotransferase activity
- chondroitin 6-sulfotransferase activity