Ercc8 Gene Summary [Mouse]
Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within response to UV and response to X-ray. Predicted to be located in nuclear matrix and perikaryon. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ercc8 |
| Official Name | excision repaiross-complementing rodent repair deficiency, complementation group 8 [Source:MGI Symbol;Acc:MGI:1919241] |
| Ensembl ID | ENSMUSG00000021694 |
| Bio databases IDs | |
| Aliases | excision repaiross-complementing rodent repair deficiency, complementation group 8 |
| Synonyms | 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, B130065P18RIK, CKN1, CSA, Csb, ERCC excision repair 8, CSA ubiquitin ligase complex subunit, excision repaiross-complementing rodent repair deficiency, complementation group 8, UVSS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ercc8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- transcription regulator
- binding protein
- WD40 repeats
- ATPase domain
- ubiquitin-protein transferase activity
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Ercc8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary disorder
- Cockayne syndrome type I
- Cockayne syndrome
- UV-sensitive syndrome type 2
- astrocytosis
- hearing loss
- Alzheimer disease
- photophobia
- schizophrenia
role in cell
- degradation in
- survival
- cell viability
- formation
- binding
- degeneration
- sensitivity
- binding in
- ubiquitination in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear matrix
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ercc8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- single strand break repair
- response to oxidative stress
- proteasomal ubiquitin-dependent protein catabolic process
- response to X-ray
- protein polyubiquitination
- transcription-coupled nucleotide-excision repair
- response to UV
- regulation of transcription-coupled nucleotide-excision repair
- response to DNA damage stimulus
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleotide-excision repair complex
- Cul4A-RING ubiquitin ligase complex
- nuclear matrix
- macromolecular complex
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding