Vgf Gene Summary [Mouse]
Enables neuropeptide hormone activity. Acts upstream of or within several processes, including insulin secretion; response to dietary excess; and response to insulin. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Predicted to be active in extracellular space and glutamatergic synapse. Is expressed in brain and thalamus. Orthologous to human VGF (VGF nerve growth factor inducible). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vgf |
| Official Name | VGF nerve growth factor inducible [Source:MGI Symbol;Acc:MGI:1343180] |
| Ensembl ID | ENSMUSG00000037428 |
| Bio databases IDs | |
| Aliases | VGF nerve growth factor inducible |
| Synonyms | Gm1052, LOC100909521, SCG7, SgVII, Vgf8a, VGF nerve growth factor inducible |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vgf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neuropeptide hormone
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- depressive disorder
- breast cancer
- organismal death
- weight gain
- bipolar disorder
- obesity
- first-onset paranoid schizophrenia
- hyperactive behavior
- survival
phenotypes
- abnormal locomotor behavior
- decreased circulating creatinine level
- decreased circulating fructosamine level
- decreased circulating glucose level
- decreased heart rate
- decreased prepulse inhibition
- decreased startle reflex
- hyperactivity
- increased circulating alanine transaminase level
- increased circulating bilirubin level
- increased circulating total protein level
- increased circulating triglyceride level
- limb grasping
- male infertility
- prolonged RR interval
- short tibia
- tremors
- abnormal adrenal medulla morphology
- abnormal adrenaline level
- abnormal circulating alanine transaminase level
- abnormal circulating creatinine level
- abnormal circulating fructosamine level
- abnormal circulating glucose level
- abnormal circulating triglyceride level
- abnormal contextual conditioning behavior
- abnormal epididymal fat pad morphology
- abnormal metabolism
- abnormal noradrenergic chromaffin cell morphology
- abnormal ovarian follicle morphology
- abnormal prepulse inhibition
- abnormal spatial learning
- abnormal tibia morphology
- absent corpus luteum
- absent estrous cycle
- absent mature ovarian follicles
- decreased body size
- decreased body weight
- decreased circulating insulin level
- decreased circulating thyroid-stimulating hormone level
- decreased circulating thyroxine level
- decreased ovary weight
- decreased oviduct weight
- decreased seminal vesicle weight
- decreased testis weight
- decreased total body fat amount
- decreased uterus weight
- decreased white adipose tissue amount
- delayed sexual maturation
- delayed vaginal opening
- hypertension
- increased basal metabolism
- increased circulating adrenaline level
- increased circulating corticosterone level
- increased lean body mass
- increased mean systemic arterial blood pressure
- increased noradrenaline level
- increased oxygen consumption
- increased systemic arterial diastolic blood pressure
- increased systemic arterial systolic blood pressure
- lactation failure
- postnatal lethality incomplete penetrance
- prolonged estrous cycle
- reduced female fertility
- reduced long term depression
- reduced male fertility
- shortened circadian behavior period
role in cell
- expression in
- cell viability
- growth
- phosphorylation in
- survival
- quantity
- differentiation
- size
- migration
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- intracellular membrane-bounded organelle
- perinuclear region
- Golgi Apparatus
- endoplasmic reticulum lumen
- synaptic vesicles
- synapse
- cytoplasmic vesicles
- secretory vesicles
- secretory granules
- membrane processes
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vgf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- insulin secretion
- signal transduction
- response to cAMP
- response to dietary excess
- defense response to bacterium
- ovarian follicle development
- response to cold
- response to insulin stimulus
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- glucose homeostasis
- carbohydrate homeostasis
- sexual reproduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- Golgi apparatus
- neuronal cell body
- transport vesicle
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- neuropeptide hormone activity
- hormone activity