Prune2 Gene Summary [Mouse]
Predicted to enable pyrophosphatase activity. Predicted to be involved in apoptotic process. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human PRUNE2 (prune homolog 2 with BCH domain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Prune2 |
| Official Name | prune homolog 2 [Source:MGI Symbol;Acc:MGI:1925004] |
| Ensembl ID | ENSMUSG00000039126 |
| Bio databases IDs | |
| Aliases | prune homolog 2 |
| Synonyms | 6330414G02Rik, A230083H22Rik, A330102H22Rik, BMCC1, BNIPXL, C9orf65, KIAA0367, LOC100129762, mKIAA0367, Olfaxin, prune homolog 2, prune homolog 2 with BCH domain, RGD1311350 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prune2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
- Divergent CRAL/TRIO domain
- CRAL/TRIO domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nodular sclerosis classical Hodgkin lymphoma
- prostate cancer
- nodular sclerosis Hodgkin disease
- uterine serous papillary cancer
- carcinoma in situ
- epithelial cancer in situ
regulates
role in cell
- binding
- binding in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- microtubules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prune2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- pyrophosphatase activity