Rasal1 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to be involved in positive regulation of dendrite extension. Predicted to be located in cytosol. Predicted to colocalize with plasma membrane. Is expressed in telencephalon mantle layer. Orthologous to human RASAL1 (RAS protein activator like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasal1 |
| Official Name | RAS protein activator like 1 (GAP1 like) [Source:MGI Symbol;Acc:MGI:1330842] |
| Ensembl ID | ENSMUSG00000029602 |
| Bio databases IDs | |
| Aliases | RAS protein activator like 1 (GAP1 like) |
| Synonyms | MRASAL, RASAL, RAS protein activator like 1, RAS protein activator like 1 (GAP1 like) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rasal1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras GTPase Activating Domain
- phospholipid binding
- GTPase-activator protein for Ras-like GTPases
- BTK motif
- GTPase-activator protein for Ras-like GTPase
- PH domain
- GTPase activator
- Pleckstrin homology-like domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- diabetes mellitus
- hepatocellular carcinoma
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- head and neck squamous cell cancer
- head and neck squamous cell carcinoma
- bladder carcinoma
- adenoid cystic carcinoma of salivary gland
role in cell
- phosphorylation in
- growth
- detyrosination in
- tyrosination in
- outgrowth in
- outgrowth
- bending
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- Plasma Membrane
- cytosol
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rasal1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Ras protein signal transduction
- cellular response to calcium ion
- signal transduction
- cell differentiation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- phospholipid binding