Thoc2 Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within several processes, including blastocyst development; regulation of mRNA export from nucleus; and stem cell division. Located in nucleus. Is expressed in brain; early conceptus; and inner cell mass. Used to study X-linked intellectual disability-short stature-overweight syndrome. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thoc2 |
| Official Name | THO complex 2 [Source:MGI Symbol;Acc:MGI:2442413] |
| Ensembl ID | ENSMUSG00000037475 |
| Bio databases IDs | |
| Aliases | THO complex 2 |
| Synonyms | 6330441O12RIK, AMC7, CXorf3, D130005M13, D130005M13Rik, dJ506G2.1, Gm1139, Gm1793, hTREX120, MRX12, MRX35, RGD1561623, THO2, THO complex 2, THO complex subunit 2, XLID12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thoc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor/nuclear export subunit protein 2
- mRNA binding
- THO complex subunit 2 N-terminus
- Transcription- and export-related complex subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked mental retardation type 12
- hereditary disorder
- infection by HIV-1
regulates
role in cell
- cell death
- survival
- development
- generation
- cell division
- sister chromatid exchange in
- accumulation in
- fragility
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thoc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- cell morphogenesis
- mRNA processing
- neuron development
- generation of neurons
- mRNA export from nucleus
- negative regulation of neuron projection development
- blastocyst development
- regulation of gene expression
- stem cell division
- regulation of mRNA export from nucleus
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear speck
- THO complex
- THO complex part of transcription export complex
- transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA binding