Kdf1 Gene Summary [Mouse]
Involved in several processes, including positive regulation of epidermal cell differentiation; regulation of epidermal cell division; and skin epidermis development. Acts upstream of or within several processes, including keratinocyte development; negative regulation of keratinocyte proliferation; and protein stabilization. Located in cell cortex; cell junction; and cell leading edge. Is expressed in several structures, including alimentary system; choroid plexus; lower urinary tract; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in ectodermal dysplasia 12. Orthologous to human KDF1 (keratinocyte differentiation factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdf1 |
| Official Name | keratinocyte differentiation factor 1 [Source:MGI Symbol;Acc:MGI:1916323] |
| Ensembl ID | ENSMUSG00000037600 |
| Bio databases IDs | |
| Aliases | keratinocyte differentiation factor 1 |
| Synonyms | 1810019J16Rik, C1orf172, ECTD12, keratinocyte differentiation factor 1, LOC100911383, RGD1303271 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4656)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- cell cortex
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte proliferation
- regulation of epidermal cell division
- positive regulation of epidermal cell differentiation
- keratinocyte proliferation
- negative regulation of stem cell proliferation
- stem cell proliferation
- morphogenesis of embryonic epithelium
- developmental growth
- establishment of skin barrier
- limb epidermis development
- keratinocyte development
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- cell leading edge
- cytoplasm
- cell cortex
- cell junction
Molecular Function
What the gene product does at the molecular level
- protein binding