Adgrl3 Gene Summary [Mouse]
Enables calcium ion binding activity. Involved in several processes, including locomotion involved in locomotory behavior; response to cocaine; and synapse organization. Acts upstream of or within positive regulation of synapse assembly. Located in axon; cell-cell junction; and plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic membrane. Is expressed in ductus deferens; epididymis; esophagus; and ileum. Used to study attention deficit hyperactivity disorder. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Adgrl3 |
| Official Name | adhesion G protein-coupled receptor L3 [Source:MGI Symbol;Acc:MGI:2441950] |
| Ensembl ID | ENSMUSG00000037605 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor L3 |
| Synonyms | 5430402I23Rik, adhesion G protein-coupled receptor L3, CIRL-3, CL3, D130075K09Rik, Gm1379, LEC3, LPHN3, mKIAA0768 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- GPCR-Autoproteolysis INducing (GAIN) domain
- cell adhesion molecule binding
- protein binding activity, bridging
- calcium ion binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- Olfactomedin-like domain
- Latrophilin Cytoplasmic C-terminal region
- GPCR proteolysis site, GPS, motif
- Galactose/rhamnose-binding lectin domain
- Galactose binding lectin domain
Pathways
Biological processes and signaling networks where the Adgrl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- measles
- chronic kidney disease
- epilepsy
- coronary artery disease
- localization-related epilepsy
- open-angle glaucoma
- ischemic stroke
- refractive error
- mucopolysaccharidosis, MPS-IV-A
regulates
- HAMP
- GH1
role in cell
- migration
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- intercellular junctions
- postsynaptic membrane
- growth cone
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- synapse assembly
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- membrane
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- calcium ion binding
- carbohydrate binding