Flrt3 Gene Summary [Mouse]
Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; proepicardium cell migration involved in pericardium morphogenesis; and synapse organization. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including axonal growth cone; cell-cell junction; and extracellular space. Is active in glutamatergic synapse and postsynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and eye. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Flrt3 |
| Official Name | fibronectin leucine rich transmembrane protein 3 [Source:MGI Symbol;Acc:MGI:1918686] |
| Ensembl ID | ENSMUSG00000051379 |
| Bio databases IDs | |
| Aliases | fibronectin leucine rich transmembrane protein 3 |
| Synonyms | 5530600M07RIK, C430047I10RIK, fibronectin leucine rich transmembrane protein 3, HH21, mKIAA1469, RGD1566005 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flrt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- chemorepellant
- FN3
- Leucine rich repeat
- protein homodimerization
- Leucine rich repeat C-terminal domain
- protein binding
- Leucine rich repeat N-terminal domain
- Fibronectin type 3 domain
- fibroblast growth factor receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- susceptibility to Kallmann syndrome type 21
- androgenic alopecia
- growth failure
- Kallmann syndrome type 21
- cardia bifida
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- diabetic peripheral neuropathy
role in cell
- adhesion
- guidance
- assembly
- distribution
- abnormal morphology
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell junction
- axon component
- Extracellular Space
- cellular membrane
- focal adhesions
- intercellular junctions
- cytosol
- postsynaptic membrane
- synaptic membrane
- growth cone
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flrt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- negative chemotaxis
- synapse assembly
- head development
- embryonic morphogenesis
- neuron projection development
- fibroblast growth factor receptor signaling pathway
- axon guidance
- response to axon injury
- positive regulation of synapse assembly
- proepicardium cell migration involved in pericardium morphogenesis
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synaptic membrane
- plasma membrane
- axon terminus
- endoplasmic reticulum membrane
- extracellular space
- cell-cell junction
- focal adhesion
- axonal growth cone
- postsynaptic membrane
- cell junction
- cytosol
- growth cone membrane
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- chemorepellent activity
- protein binding, bridging
- fibroblast growth factor receptor binding