Flrt1 Gene Summary [Mouse]
Enables fibroblast growth factor receptor binding activity. Involved in dendrite development; fibroblast growth factor receptor signaling pathway; and neuron projection extension. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including neuron projection terminus; neuronal cell body membrane; and perinuclear region of cytoplasm. Colocalizes with focal adhesion. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; neural ectoderm; and sensory organ. Orthologous to human FLRT1 (fibronectin leucine rich transmembrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flrt1 |
| Official Name | fibronectin leucine rich transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:3026647] |
| Ensembl ID | ENSMUSG00000047787 |
| Bio databases IDs | |
| Aliases | fibronectin leucine rich transmembrane protein 1 |
| Synonyms | D630040I23RIK, fibronectin leucine rich transmembrane protein 1, RGD1565152, RP11 21A7A2, SPG68 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flrt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- FN3
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- Leucine rich repeat N-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- Fibronectin type 3 domain
- fibroblast growth factor receptor binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- perinuclear region
- cellular membrane
- focal adhesions
- intercellular junctions
- nerve ending
- cytoplasmic vesicles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flrt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast growth factor receptor signaling pathway
- cell adhesion
- dendrite development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- cytoplasmic vesicle membrane
- cell-cell junction
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasmic vesicle
- neuronal cell body membrane
- extracellular matrix
- neuron projection terminus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding, bridging