Tecta Gene Summary [Mouse]
An extracellular matrix structural constituent. Acts upstream of or within auditory receptor cell stereocilium organization. Located in extracellular matrix. Is expressed in inner ear. Used to study autosomal dominant nonsyndromic deafness 12. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Orthologous to human TECTA (tectorin alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tecta |
| Official Name | tectorin alpha [Source:MGI Symbol;Acc:MGI:109575] |
| Ensembl ID | ENSMUSG00000037705 |
| Bio databases IDs | |
| Aliases | tectorin alpha |
| Synonyms | Alpha Tectorin, DFNA12, DFNA8, DFNB21, Tctna, tectorin alpha, tectorin α, α Tectorin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tecta often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nidogen-like
- von Willebrand factor type D domain
- extracellular matrix structural constituent
- enzyme
- protein binding
- C8 domain
- Trypsin Inhibitor like cysteine rich domain
- von Willebrand factor type C domain
- Zona pellucida (ZP) domain
- Zona pellucida-like domain
- trypsin inhibitor-like cysteine rich domain
- von Willebrand factor (vWF) type D domain
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sporadic age-related sensorineural hearing loss
- familial nonsyndromic hearing impairment
- endolymphatic hydrops
- melanoma cancer
- hereditary age-related sensorineural hearing loss
- melanoma
- autosomal dominant deafness 12
- vertigo
- autosomal recessive deafness type 21
role in cell
- function
- mechanotransduction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Plasma Membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tecta gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- auditory receptor cell stereocilium organization
- sensory perception of sound
- cell-matrix adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular matrix
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent