Fmnl1 Gene Summary [Mouse]
Enables several functions, including GTPase activating protein binding activity; profilin binding activity; and small GTPase binding activity. Involved in actin filament severing. Acts upstream of or within substrate-dependent cell migration. Located in cytosol; phagocytic vesicle; and plasma membrane. Is expressed in several structures, including gut; heart; immune system; liver; and lung. Orthologous to human FMNL1 (formin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmnl1 |
| Official Name | formin-like 1 [Source:MGI Symbol;Acc:MGI:1888994] |
| Ensembl ID | ENSMUSG00000055805 |
| Bio databases IDs | |
| Aliases | formin-like 1 |
| Synonyms | 8030453N10Rik, AI553564, C17orf1, C17orf1B, FHOD4, FMNL, Fnrl, formin-like 1, Frls, KW-13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmnl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- actin filament binding
- formin homology domain 1
- Nuf2, DHR10-like domain
- Diaphanous FH3 Domain
- enzyme binding
- diaphanous autoregulatory domain
- protein binding
- Diaphanous GTPase-binding Domain
- profilin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- organismal death
- dementia
- androgenic alopecia
- hypothyroidism
- metastasis
- periodontitis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- nasopharyngeal carcinoma
regulated by
- severe acute respiratory syndrome coronavirus 2
- IGF1
- PAGA
- dexamethasone
- ACH-2 cells
- tributyltin
- AGN194204
- j1.1 cells
- MIR16
- U1 cells
role in cell
- expression in
- proliferation
- migration
- formation
- formation in
- binding in
- elongation
- reorientation
- invasiveness
- severing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- sarcomere
- cytosol
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmnl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cortical actin cytoskeleton organization
- actin filament severing
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cell cortex
- membrane
- phagocytic vesicle
- cytosol
- bleb
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- small GTPase binding
- GTPase activating protein binding