Pdss2 Gene Summary [Mouse]
Enables protein heterodimerization activity. Contributes to all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity. Involved in cerebellum development; isoprenoid biosynthetic process; and ubiquinone biosynthetic process. Acts upstream of or within regulation of body fluid levels. Located in mitochondrion. Part of heterotetrameric polyprenyl diphosphate synthase complex and ubiquinone biosynthesis complex. Is expressed in several structures, including endocrine gland; genitourinary system; heart; nervous system; and stomach. Used to study coenzyme Q10 deficiency disease. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 3. Orthologous to human PDSS2 (decaprenyl diphosphate synthase subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Pdss2 |
| Official Name | prenyl (solanesyl) diphosphate synthase, subunit 2 [Source:MGI Symbol;Acc:MGI:1918615] |
| Ensembl ID | ENSMUSG00000038240 |
| Bio databases IDs | |
| Aliases | prenyl (solanesyl) diphosphate synthase, subunit 2 |
| Synonyms | 5430420P03Rik, bA59I9.3, C6orf210, COQ10D3, COQ1B, decaprenyl diphosphate synthase subunit 2, DLP1, Gm60, hDLP1, kd, LOC57107, mDLP1, Plmp, prenyl (solanesyl) diphosphate synthase, subunit 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdss2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- all-trans-decaprenyl-diphosphate synthase
- Isoprenoid Biosynthesis enzymes, Class 1
- prenyltransferase
- enzyme
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- primary coenzyme Q10 deficiency type 3
- coronary artery disease
- nephrosis
- microalbuminuria
- Leigh syndrome
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdss2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellum development
- regulation of body fluid levels
- isoprenoid biosynthetic process
- ubiquinone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytosol
- heterotetrameric decaprenyl diphosphate synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- all-trans-decaprenyl-diphosphate synthase activity
- prenyltransferase activity
- protein heterodimerization activity
- all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity