Pdss2 Gene Summary [Rat]
Predicted to enable prenyltransferase activity and protein heterodimerization activity. Predicted to contribute to all-trans-decaprenyl-diphosphate synthase activity and all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity. Predicted to be involved in cerebellum development; isoprenoid biosynthetic process; and ubiquinone biosynthetic process. Predicted to act upstream of or within regulation of body fluid levels. Predicted to be located in cytosol. Predicted to be part of heterotetrameric polyprenyl diphosphate synthase complex and ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 3. Orthologous to human PDSS2 (decaprenyl diphosphate synthase subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdss2 |
| Official Name | decaprenyl diphosphate synthase subunit 2 [Source:RGD Symbol;Acc:1359372] |
| Ensembl ID | ENSRNOG00000042962 |
| Bio databases IDs | |
| Aliases | decaprenyl diphosphate synthase subunit 2 |
| Synonyms | 5430420P03Rik, bA59I9.3, C6orf210, COQ10D3, COQ1B, decaprenyl diphosphate synthase subunit 2, DLP1, Gm60, hDLP1, kd, LOC57107, mDLP1, Plmp, prenyl (solanesyl) diphosphate synthase, subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdss2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- all-trans-decaprenyl-diphosphate synthase
- Isoprenoid Biosynthesis enzymes, Class 1
- prenyltransferase
- enzyme
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- primary coenzyme Q10 deficiency type 3
- coronary artery disease
- nephrosis
- microalbuminuria
- Leigh syndrome
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdss2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellum development
- regulation of body fluid levels
- isoprenoid biosynthetic process
- ubiquinone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytosol
- heterotetrameric decaprenyl diphosphate synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- all-trans-decaprenyl-diphosphate synthase activity
- prenyltransferase activity
- protein heterodimerization activity
- all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity