Iffo1 Gene Summary [Mouse]
Predicted to be involved in DNA double-strand break attachment to nuclear envelope; double-strand break repair via nonhomologous end joining; and protein localization to site of double-strand break. Predicted to be located in nuclear matrix; nucleoplasm; and site of double-strand break. Is expressed in diaphragm; embryo mesenchyme; and musculature. Orthologous to human IFFO1 (intermediate filament family orphan 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iffo1 |
| Official Name | intermediate filament family orphan 1 [Source:MGI Symbol;Acc:MGI:2444516] |
| Ensembl ID | ENSMUSG00000038271 |
| Bio databases IDs | |
| Aliases | intermediate filament family orphan 1 |
| Synonyms | 4733401N06Rik, A930037G23Rik, HOM-TES-103, IFFO, intermediate filament family orphan 1, RGD1308257 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iffo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iffo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- site of double-strand break
- nuclear matrix
- intermediate filament
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding