IFFO1 Gene Summary [Human]

This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Details

Type
Retained Intron
Official Symbol
IFFO1
Official Name
intermediate filament family orphan 1 [Source:HGNC Symbol;Acc:HGNC:24970]
Ensembl ID
ENSG00000010295
Bio databases IDs NCBI: 25900 Ensembl: ENSG00000010295
Aliases intermediate filament family orphan 1
Synonyms 4733401N06Rik, A930037G23Rik, HOM-TES-103, IFFO, intermediate filament family orphan 1, RGD1308257
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFFO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding
  • Intermediate filament protein

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • obsessive-compulsive disorder
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm
  • nuclear matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human IFFO1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • double-strand break repair via nonhomologous end joining

Cellular Component

Where in the cell the gene product is active
  • nuclear inner membrane
  • site of double-strand break
  • nuclear matrix
  • intermediate filament
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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