Mlxip Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within nucleocytoplasmic transport. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; craniocervical region bone; rib; testis; and urinary system. Orthologous to human MLXIP (MLX interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlxip |
| Official Name | MLX interacting protein [Source:MGI Symbol;Acc:MGI:2141183] |
| Ensembl ID | ENSMUSG00000038342 |
| Bio databases IDs | |
| Aliases | MLX interacting protein |
| Synonyms | bHLHe36, KIAA0867, MIR, MLX interacting protein, MONDOA, RGD1560774 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlxip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- NES2-NLS_ChREBP-like
- transcription regulator
- basic helix-loop-helix-leucine zipper domain
- nucleic acid binding
- double-stranded DNA binding
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- osteoarthritis
- ischemic stroke
- schizophrenia
- gout
- splenomegaly
- hepatomegaly
- immunodeficiency
phenotypes
- abnormal muscle physiology
- decreased respiratory quotient
- enhanced exercise endurance
- increased circulating alanine level
- increased circulating lactate level
- increased fatty acid oxidation
role in cell
- proliferation
- colony formation
- number
- survival
- transcription in
- oxidative phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlxip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial outer membrane
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity