Car14 Gene Summary [Mouse]
Enables carbonate dehydratase activity. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; cranium; early conceptus; sensory organ; and urinary system. Orthologous to human CA14 (carbonic anhydrase 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Car14 |
| Official Name | carbonic anhydrase 14 [Source:MGI Symbol;Acc:MGI:1344341] |
| Ensembl ID | ENSMUSG00000038526 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 14 |
| Synonyms | Car14, carbonic anhydrase 14, CA-XIV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Car14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- alpha_CA
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- cardiovascular death
- myocardial infarction
- essential hypertension
- metabolic syndrome X
- stroke
- prehypertension
- diabetic nephropathy
- disorder of coronary artery
- heart failure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
- membrane processes
- microvilli
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Car14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- carbonate dehydratase activity