Cyp24a1 Gene Summary [Mouse]
The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Cyp24a1 |
| Official Name | cytochrome P450, family 24, subfamily a, polypeptide 1 [Source:MGI Symbol;Acc:MGI:88593] |
| Ensembl ID | ENSMUSG00000038567 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 24, subfamily a, polypeptide 1 |
| Synonyms | 1,25-dihydroxyvitamin d3 24-hydroxylase, 24-Hydroxylase, 24-OHase, 24R-Ohase, Calcidiol 24-Hydroxylase, CP24, CYP24, cytochrome P450 family 24 subfamily A member 1, cytochrome P450, family 24, subfamily a, polypeptide 1, HCAI, HCINF1, P450c24, P450-CC24, Vitamin d-24-hydroxylase, VITD12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp24a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- vitamin D3 25-hydroxylase
- 25-hydroxycholecalciferol-24-hydroxylase
- enzyme
- steroid hydroxylase
- heme binding
- 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase
Pathways
Biological processes and signaling networks where the Cyp24a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- multiple sclerosis
- infantile hypercalcemia type 1
- prostate cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- insulin-dependent diabetes mellitus
- atopic dermatitis
role in cell
- proliferation
- production in
- apoptosis
- accumulation in
- migration
- synthesis in
- binding in
- senescence
- mitosis
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp24a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to vitamin D
- vitamin D receptor signaling pathway
- osteoblast differentiation
- vitamin metabolic process
- vitamin D catabolic process
- vitamin D metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- iron ion binding
- vitamin D 25-hydroxylase activity
- 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
- 25-hydroxycholecalciferol-24-hydroxylase activity
- heme binding