Ensa Gene Summary [Mouse]
Predicted to enable several functions, including potassium channel inhibitor activity; protein phosphatase 2A binding activity; and protein phosphatase inhibitor activity. Predicted to be involved in G2/M transition of mitotic cell cycle. Predicted to act upstream of or within regulation of insulin secretion. Predicted to be active in cytoplasm. Is expressed in central nervous system; genitourinary system; retina; and skin. Orthologous to human ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | To be Experimentally Confirmed |
| Official Symbol | Ensa |
| Official Name | endosulfine alpha [Source:MGI Symbol;Acc:MGI:1891189] |
| Ensembl ID | ENSMUSG00000038619 |
| Bio databases IDs | |
| Aliases | endosulfine alpha |
| Synonyms | 1700020C18Rik, 2610007F17Rik, Alpha-endosulfine, ARPP-19e, endosulfine alpha, endosulfine α, α-endosulfine |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ensa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel inhibitor
- phosphatase inhibitor
- cAMP-regulated phosphoprotein/endosulfine conserved region
- protein phosphatase binding
- protein phosphatase regulator
- protein binding
- receptor binding
- potassium channel inhibitor
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- neoplasia
- breast cancer
- organismal death
- HER2 negative hormone receptor negative breast cancer
- epidermal inclusion cyst
- heart disease
role in cell
- expression in
- binding
- growth
- mitotic entry
- formation
- misalignment
- misalignment in
- formation in
- stattic sensitivity
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ensa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of insulin secretion
- G2/M transition of mitotic cell cycle
- response to nutrient
- negative regulation of protein dephosphorylation
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- potassium channel inhibitor activity
- phosphatase inhibitor activity
- ion channel inhibitor activity
- receptor binding
- protein phosphatase 2A binding
- protein phosphatase regulator activity