Ttll6 Gene Summary [Mouse]
Enables tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation and regulation of cilium beat frequency involved in ciliary motility. Acts upstream of or within microtubule bundle formation; microtubule severing; and positive regulation of cilium movement. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in several structures, including branchial arch; early embryo; genitourinary system; inner ear; and primitive streak. Orthologous to human TTLL6 (tubulin tyrosine ligase like 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttll6 |
| Official Name | tubulin tyrosine ligase-like family, member 6 [Source:MGI Symbol;Acc:MGI:2683461] |
| Ensembl ID | ENSMUSG00000038756 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase-like family, member 6 |
| Synonyms | 4932418K24Rik, D11Moh43e, D11Moh44e, RGD1311922, t8130b59, Ttll6-ps1, tubulin tyrosine ligase like 6, tubulin tyrosine ligase-like family, member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttll6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid-D-amino acid ligase
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- tubulin binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- non-motile cilium
- cilia
- basal bodies
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttll6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyglutamylation
- microtubule severing
- microtubule bundle formation
- regulation of cilium beat frequency involved in ciliary motility
- microtubule cytoskeleton organization
- positive regulation of cilium movement
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- cilium
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein-glutamic acid ligase activity
- ATP binding
- tubulin binding
- protein binding
- metal ion binding
- tubulin-glutamic acid ligase activity