Ulk4 Gene Summary [Mouse]
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Acts upstream of or within several processes, including adult walking behavior; cilium organization; and nervous system development. Is active in cilium. Is expressed in brain. Used to study hydrocephalus and schizophrenia. Orthologous to human ULK4 (unc-51 like kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ulk4 |
| Official Name | unc-51-like kinase 4 [Source:MGI Symbol;Acc:MGI:1921622] |
| Ensembl ID | ENSMUSG00000040936 |
| Bio databases IDs | |
| Aliases | unc-51-like kinase 4 |
| Synonyms | 4932415A06RIK, A730098P15, DKFZP434E1822, FAM7C1, REC01035, RGD1565726, unc-51-like kinase 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ulk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- alcoholic liver disease
- myopia
- plasma cell myeloma
- paraproteinemia
- major depression
- ischemic stroke
- alcoholism
- hypertension
role in cell
- quantity
- differentiation
- movement
- assembly
- development
- disorganization
- organization
- migration by
- number
- disorganization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ulk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- regulation of protein kinase C signaling cascade
- microtubule cytoskeleton organization
- regulation of neuron projection development
- regulation of p38MAPK cascade
- regulation of neuron migration
- regulation of JNK cascade
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity