Sde2 Gene Summary [Mouse]
Predicted to enable damaged DNA binding activity and snoRNA binding activity. Predicted to be involved in several processes, including cellular response to UV; gene expression; and mitotic G1 DNA damage checkpoint signaling. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in nucleus. Is expressed in submandibular gland primordium and thymus primordium. Orthologous to human SDE2 (SDE2 telomere maintenance homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sde2 |
| Official Name | SDE2 telomere maintenance homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:2384788] |
| Ensembl ID | ENSMUSG00000038806 |
| Bio databases IDs | |
| Aliases | SDE2 telomere maintenance homolog (S. pombe) |
| Synonyms | C1orf55, dJ671D7.1, RGD1305572, SDE2 telomere maintenance homolog, SDE2 telomere maintenance homolog (S. pombe) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sde2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- snoRNA binding
- protein binding
- Replication stress response SDE2 C-terminal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sde2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- nuclear mRNA cis splicing, via spliceosome
- mitotic cell cycle G1/S transition DNA damage checkpoint
- DNA replication
- cellular response to UV
- protein processing
- endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- snoRNA binding
- damaged DNA binding