Hoxb6 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; embryonic skeletal system morphogenesis; and erythrocyte homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human HOXB6 (homeobox B6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxb6 |
| Official Name | homeobox B6 [Source:MGI Symbol;Acc:MGI:96187] |
| Ensembl ID | ENSMUSG00000000690 |
| Bio databases IDs | |
| Aliases | homeobox B6 |
| Synonyms | homeo box B6, HOX2, Hox-2.2, HOX2B, HU-2, RGD1562142 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxb6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Pbx binding domain
- DNA binding domain
- double-stranded DNA binding
- protein binding
- glutamic acid-rich domain
- sequence-specific DNA binding
- homeodomain
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign neoplasia
- endometriosis
- survival
- squamous-cell carcinoma
- squamous cell cancer
- pancreatic cancer
- metabolic syndrome X
- colorectal cancer
- psoriasis
- dermatofibroma
regulates
- gamma globin
- reporter gene
- hemoglobin alpha
- CREBBP
role in cell
- homeostasis
- quantity
- immortalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxb6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte homeostasis
- anterior/posterior pattern specification
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity