Hoxa5 Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within several processes, including intestinal epithelial cell maturation; mammary gland development; and respiratory system development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and skeleton. Orthologous to human HOXA5 (homeobox A5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxa5 |
| Official Name | homeobox A5 [Source:MGI Symbol;Acc:MGI:96177] |
| Ensembl ID | ENSMUSG00000038253 |
| Bio databases IDs | |
| Aliases | homeobox A5 |
| Synonyms | homeo box A5, HOX1, HOX1.3, HOX1C, LOC100909641, LOC100911546, LOC103689922, LOC103692127 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxa5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- hexapeptide domain
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
- DNA binding
- YPWMK motif
Pathways
Biological processes and signaling networks where the Hoxa5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pulmonary emphysema
- hypoplasia
- growth failure
- metastasis
- stenosis
- uterine leiomyoma
- leiomyomatosis
- HER2 negative hormone receptor negative breast cancer
- rotator cuff injury
role in cell
- production in
- migration
- differentiation
- proliferation
- expression in
- phosphorylation in
- cell viability
- growth
- apoptosis
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxa5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- multicellular organism growth
- epithelial tube branching involved in lung morphogenesis
- negative regulation of angiogenesis
- lung goblet cell differentiation
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of erythrocyte differentiation
- cell-cell signaling involved in mammary gland development
- mammary gland epithelial cell differentiation
- lung alveolus development
- mammary gland alveolus development
- regulation of mammary gland epithelial cell proliferation
- cell migration
- intestinal epithelial cell maturation
- positive regulation of myeloid cell differentiation
- mesenchymal-epithelial cell signaling
- embryonic skeletal system morphogenesis
- bronchiole development
- trachea cartilage morphogenesis
- regulation of transcription from RNA polymerase II promoter
- respiratory system process
- thyroid gland development
- positive regulation of gene expression
- positive regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity