Supt3 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of SAGA complex. Is expressed in bladder; ovary; testis; urethra of female; and urethra of male. Orthologous to human SUPT3H (SPT3 homolog, SAGA and STAGA complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Supt3 |
| Official Name | SPT3, SAGA and STAGA complex component [Source:MGI Symbol;Acc:MGI:1923723] |
| Ensembl ID | ENSMUSG00000038954 |
| Bio databases IDs | |
| Aliases | SPT3, SAGA and STAGA complex component |
| Synonyms | 2310066G22Rik, LOC683926, SPT3, SPT3 homolog, SAGA and STAGA complex component, SPT3L, SPT3, SAGA and STAGA complex component, Supt3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Supt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- transcription co-activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- pain
- non-insulin-dependent diabetes mellitus
- diffuse idiopathic skeletal hyperostosis
- fracture of bone
- male pattern hair loss
- attention deficit hyperactivity disorder
- otosclerosis
regulates
- DNA promoter
- DNA endogenous promoter
- histone
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Supt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- regulation of DNA repair
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFTC complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription coactivator activity
- protein heterodimerization activity