Chad Gene Summary [Mouse]
Acts upstream of or within bone development and negative regulation of bone trabecula formation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including cartilage; sensory organ; skeleton; trachea cartilaginous ring; and ventral body wall. Orthologous to human CHAD (chondroadherin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chad |
| Official Name | chondroadherin [Source:MGI Symbol;Acc:MGI:1096866] |
| Ensembl ID | ENSMUSG00000039084 |
| Bio databases IDs | |
| Aliases | chondroadherin |
| Synonyms | chondroadherin, SLRR4A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chad often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- heparin binding domain
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine rich repeat N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- adenoid cystic carcinoma of salivary gland
- salivary gland cancer
- androgenic alopecia
regulates
- ERK
- ERK1/2
- CHAD
- Collagen type II
role in cell
- adhesion
- phosphorylation in
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chad gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of bone trabecula formation
- bone development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix