Htra1 Gene Summary [Mouse]
Enables serine-type peptidase activity. Involved in proteolysis. Acts upstream of or within chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; genitourinary system; heart; limb; and sensory organ. Human ortholog(s) of this gene implicated in CADASIL (multiple); gastrointestinal system cancer (multiple); hypertension; lung adenocarcinoma; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Htra1 |
| Official Name | HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI:1929076] |
| Ensembl ID | ENSMUSG00000006205 |
| Bio databases IDs | |
| Aliases | HtrA serine peptidase 1 |
| Synonyms | ARMD7, CADASIL2, CARASIL, HTRA, HtrA serine peptidase 1, IGFBP5-protease, L56, ORF480, OTTHUMP00000020664, OTTHUMP00000063514, Protease do precursor, PRSS11, PRSSS, RSPP11, SERINE PROTEASE 11/IGF binding |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Htra1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tryp_SPc
- peptidase
- protein binding
- PDZ domain
- KAZAL_FS
- identical protein binding
- trypsin
- serine endopeptidase
- serine-type peptidase
- Trypsin-like peptidase domain
- Insulin-like growth factor binding protein
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Htra1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- endometrial cancer
- COVID-19
- coronary artery disease
- Alzheimer disease
- CADASIL 2
- osteoarthritis
- spontaneous coronary artery dissection
- age-related macular degeneration
- age-related macular degeneration type 7
role in cell
- growth
- proliferation
- expression in
- invasion by
- cell death
- activation in
- differentiation
- degeneration
- invasiveness
- anoikis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Nucleus
- Plasma Membrane
- photoreceptor outer segments
- photoreceptor inner segments
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Htra1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- chorionic trophoblast cell differentiation
- positive regulation of apoptotic process
- proteolysis
- placenta development
- programmed cell death
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- growth factor binding
- protein binding
- serine-type peptidase activity
- serine-type endopeptidase activity