Stx11 Gene Summary [Mouse]
Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within cellular response to type II interferon and leukocyte degranulation. Located in phagocytic vesicle. Is expressed in appendicular skeleton; brain; heart; and pancreas. Used to study familial hemophagocytic lymphohistiocytosis 4. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 4. Orthologous to human STX11 (syntaxin 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx11 |
| Official Name | syntaxin 11 [Source:MGI Symbol;Acc:MGI:1921982] |
| Ensembl ID | ENSMUSG00000039232 |
| Bio databases IDs | |
| Aliases | syntaxin 11 |
| Synonyms | 5830405C08Rik, FHL4, HLH4, HPLH4, LOC102549741, syntaxin 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- SynN
- Helical region found in SNAREs
- Syntaxin
- protein binding
- SNARE motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- thrombocytopenia
- familial hemophagocytic lymphohistiocytosis type 4
- Alzheimer disease
- breast adenocarcinoma
- Waldenström macroglobulinemia
- lung adenocarcinoma
- familial hemophagocytic lymphohistiocytosis
- weight loss
- pancytopenia
role in cell
- number
- morphology
- fusion
- activation
- function
- response by
- cytolysis by
- degranulation
- fusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular compartment
- intracellular space
- perinuclear region
- cellular membrane
- endosomes
- lysosome
- granules
- apical membrane
- basolateral membrane
- trans Golgi network
- vacuolar apical compartments
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- vesicle docking
- synaptic vesicle fusion to presynaptic membrane
- intracellular protein transport
- exocytosis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- endomembrane system
- SNARE complex
- Golgi apparatus
- presynaptic active zone membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding