Exosc2 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in RNA metabolic process and positive regulation of cell growth. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including cerebral cortex; gonad; liver; metanephros; and muscle tissue. Human ortholog(s) of this gene implicated in short stature, hearing loss, retinitis pigmentosa, and distinctive facies. Orthologous to human EXOSC2 (exosome component 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exosc2 |
| Official Name | exosome component 2 [Source:MGI Symbol;Acc:MGI:2385133] |
| Ensembl ID | ENSMUSG00000039356 |
| Bio databases IDs | |
| Aliases | exosome component 2 |
| Synonyms | exosome component 2, hRrp4p, p7, RRP4, Rrp4p, SHRF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Exosc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- 7S RNA binding
- S1_like
- K homology (KH) RNA-binding domain, type I
- KH domain
- enzyme
- protein binding
- Exosome complex exonuclease RRP4 N-terminal region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Exosc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- U4 snRNA 3'-end processing
- nuclear-transcribed mRNA catabolic process
- RNA processing
- rRNA processing
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- RNA catabolic process
- positive regulation of cell growth
- polyadenylation-dependent snoRNA 3'-end processing
- nuclear polyadenylation-dependent rRNA catabolic process
- CUT catabolic process
- nuclear polyadenylation-dependent tRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nucleus
- nuclear exosome (RNase complex)
- cytoplasm
- cytosol
- nucleolus
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- 7S RNA binding
- exoribonuclease activity