Nrde2 Gene Summary [Mouse]
Predicted to be involved in several processes, including RNA splicing; negative regulation of macromolecule metabolic process; and positive regulation of RNA export from nucleus. Predicted to be located in nuclear speck and nucleolus. Orthologous to human NRDE2 (NRDE-2, necessary for RNA interference, domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrde2 |
| Official Name | nrde-2 necessary for RNA interference, domain containing [Source:MGI Symbol;Acc:MGI:2670969] |
| Ensembl ID | ENSMUSG00000021179 |
| Bio databases IDs | |
| Aliases | nrde-2 necessary for RNA interference, domain containing |
| Synonyms | 6720454P05Rik, C14orf102, nrde-2 necessary for RNA interference, domain containing, NRDE-2, necessary for RNA interference, domain containing, RGD1565082 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrde2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NRDE-2, necessary for RNA interference
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrde2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- RNA splicing
- mRNA stabilization
- mRNA processing
- response to DNA damage stimulus
- mitotic cell cycle
- chromatin silencing by small RNA
- positive regulation of RNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding