Rnf8 Gene Summary [Mouse]
Enables histone binding activity and ubiquitin protein ligase activity. Involved in DNA metabolic process; signal transduction in response to DNA damage; and sperm DNA condensation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in central nervous system; genitourinary system; nasal cavity epithelium; and thymus primordium. Orthologous to human RNF8 (ring finger protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf8 |
| Official Name | ring finger protein 8 [Source:MGI Symbol;Acc:MGI:1929069] |
| Ensembl ID | ENSMUSG00000090083 |
| Bio databases IDs | |
| Aliases | ring finger protein 8 |
| Synonyms | 3830404E21Rik, AIP37, hRNF8, laXp180, ring finger protein 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- histone binding
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- Forkhead associated domain
- coiled-coil domain
- chromatin binding
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- forkhead associated (FHA) domain superfamily
- zinc ion binding
- RING-type zinc-finger
- FHA domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- protein homodimerization
- tail domain
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Rnf8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- prostate cancer
- organismal death
- hepatocellular carcinoma
- liver cancer
role in cell
- survival
- expression in
- damage in
- formation
- formation in
- proliferation
- phosphorylation in
- replication in
- accumulation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- protein K48-linked ubiquitination
- negative regulation of transcription elongation from RNA polymerase II promoter
- signal transduction in response to DNA damage
- sperm chromatin condensation
- response to DNA damage stimulus
- double-strand break repair via nonhomologous end joining
- regulation of gene expression, epigenetic
- double-strand break repair
- ubiquitin-dependent protein catabolic process
- cell division
- protein K63-linked ubiquitination
- protein K6-linked ubiquitination
- isotype switching
- protein autoubiquitination
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- site of double-strand break
- ubiquitin ligase complex
- cytosol
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- ubiquitin binding
- histone binding
- chromatin binding