Dse Gene Summary [Mouse]
Predicted to enable chondroitin-glucuronate 5-epimerase activity. Predicted to be involved in chondroitin sulfate proteoglycan metabolic process and dermatan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; endocrine gland; genitourinary system; and oral epithelium. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome musculocontractural type 2. Orthologous to human DSE (dermatan sulfate epimerase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dse |
| Official Name | dermatan sulfate epimerase [Source:MGI Symbol;Acc:MGI:2443455] |
| Ensembl ID | ENSMUSG00000039497 |
| Bio databases IDs | |
| Aliases | dermatan sulfate epimerase |
| Synonyms | 6030499O08, B130024B19Rik, dermatan sulfate epimerase, dermatan sulphate epimerase, DSEP, DSEPI, DS-EPI1, EDSMC2, LOC100506515, LOC100652996, RP1 93H181, RP3 486I37, SART2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dse often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chondroitin-glucuronate 5-epimerase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- endometriosis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- sudden infant death with dysgenesis of the testes syndrome
- systemic lupus erythematosus
- musculocontractural Ehlers-Danlos syndrome type 2
role in cell
- expression in
- proliferation
- formation in
- formation
- signaling in
- binding
- migration
- invasiveness
- abnormal morphology
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- secretory vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dse gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- dermatan sulfate metabolic process
- dermatan sulfate biosynthetic process
- heparan sulfate proteoglycan biosynthetic process
- chondroitin sulfate metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- endoplasmic reticulum
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- chondroitin-glucuronate 5-epimerase activity