Cadm2 Gene Summary [Mouse]
Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in axon. Predicted to be active in neuronal cell body membrane. Is expressed in bone; central nervous system; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in autism spectrum disorder; malignant astrocytoma; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cadm2 |
| Official Name | cell adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:2442722] |
| Ensembl ID | ENSMUSG00000064115 |
| Bio databases IDs | |
| Aliases | cell adhesion molecule 2 |
| Synonyms | 2900078E11RIK, 9330131D06, A830029E02Rik, cell adhesion molecule 2, Igdf4d, IGSF4D, NECL3, SynCAM-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cadm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- putative band 4.1 homologues' binding motif
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- bipolar I disorder
- major depression
- sunburn
- dyslexia
- gout
- COVID-19
- benign rolandic epilepsy
- pervasive developmental disorder
role in cell
- accumulation in
- proliferation
- expression in
- migration
- adhesion
- invasion by
- clustering in
- diffusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- postsynaptic membrane
- synapse
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cadm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- neuronal cell body membrane
- synapse
- axon
- plasma membrane