Mt1 Gene Summary [Mouse]

Enables copper ion binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including cellular response to chromate; cellular response to zinc ion; and intracellular zinc ion homeostasis. Located in cytosol and lysosome. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; sensory organ; and ventricular layer. Orthologous to several human genes including MT1F (metallothionein 1F). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Mt1
Official Name
metallothionein 1 [Source:MGI Symbol;Acc:MGI:97171]
Ensembl ID
ENSMUSG00000031765
Bio databases IDs NCBI: 17748 Ensembl: ENSMUSG00000031765
Aliases metallothionein 1
Synonyms METALLOTHIONEIN 1, Metallothionein2, Mt, Mt1a, MT1B, Mt2, MT-I
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • copper ion binding
  • metallothionein beta domain
  • zinc ion binding
  • metallothionein alpha domain
  • Metallothionein
  • metal ion binding

Pathways

Biological processes and signaling networks where the Mt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • epithelial neoplasia
  • neoplasia
  • abdominal cancer
  • cancer
  • epithelial cancer
  • neuropathy
  • tubulo-interstitial fibrosis
  • hyperplasia
  • hepatic fibrosis
  • clonic seizure
regulated by
  • lipopolysaccharide
  • diethylnitrosamine
  • MYC
  • APP
  • dexamethasone
  • D-glucose
  • PCSK9
  • NR1H3
  • oleic acid
  • palmitic acid
regulates
role in cell
  • expression in
  • formation
  • growth
  • number
  • cell death
  • proliferation
  • apoptosis
  • cell viability
  • function
  • survival

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • lysosome
  • Mitochondria
  • cytosol
  • mitochondrial intermembrane space

Gene-Specific Assays for Results You Can Trust

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