Septin2 Gene Summary [Mouse]
Enables enzyme regulator activity. Involved in cilium assembly and smoothened signaling pathway. Acts upstream of or within regulation of L-glutamate import across plasma membrane and regulation of protein localization. Located in several cellular components, including cell surface; ciliary membrane; and ciliary transition zone. Part of septin complex. Is expressed in several structures, including 1st branchial arch; brain; cochlea; limb; and testis. Orthologous to human SEPTIN2 (septin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin2 |
| Official Name | septin 2 [Source:MGI Symbol;Acc:MGI:97298] |
| Ensembl ID | ENSMUSG00000026276 |
| Bio databases IDs | |
| Aliases | septin 2 |
| Synonyms | DIFF6, hNedd5, mKIAA0158, NEDD-5, Pnutl3, SEPT2, Vesp11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Septin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase
- enzyme
- protein binding
- enzyme regulator activity
- identical protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- insulin-dependent diabetes mellitus
- prostatic carcinoma
- prostate cancer
- early onset hypertension
- male pattern hair loss
- cleft lip
role in cell
- apoptosis
- migration
- number
- growth
- fragmentation
- assembly
- colony formation by
- invasion by
- cell abscission in
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- mitochondrial fission sites
- microtubule cytoskeleton
- ciliary transition zone
- sperm annulus
- non-motile cilium
- presynaptic regions
- cilia
- cell surface
- perinuclear region
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- vesicles
- axonemes
- contractile rings
- actin filaments
- midbody
- cytoplasmic bridges
- connecting cilia
- nucleoplasm
- spindle fibers
- growth cone
- neurites
- synaptosomes
- synapse
- cleavage furrow
- cellular protrusions
- central spindle
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Septin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- spermatogenesis
- cell differentiation
- protein localization
- smoothened signaling pathway
- regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- microtubule cytoskeleton
- cell division site
- cleavage furrow
- synaptic vesicle
- kinetochore
- axoneme
- plasma membrane
- septin ring
- nucleoplasm
- nucleus
- intercellular bridge
- extracellular vesicular exosome
- cytoplasm
- cell cortex
- sperm annulus
- spindle
- actin cytoskeleton
- cilium membrane
- midbody
- septin complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- cadherin binding
- binding, bridging