Vasn Gene Summary [Mouse]
Predicted to enable transforming growth factor beta binding activity. Acts upstream of or within cellular response to hypoxia and cellular response to redox state. Located in mitochondrion and plasma membrane. Is expressed in several structures, including cardiovascular system; cranium; embryo mesenchyme; genitourinary system; and gut. Orthologous to human VASN (vasorin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vasn |
| Official Name | vasorin [Source:MGI Symbol;Acc:MGI:2177651] |
| Ensembl ID | ENSMUSG00000039646 |
| Bio databases IDs | |
| Aliases | vasorin |
| Synonyms | 2610528G05Rik, Atia, CSRV314, Loc114990, LOC687214, MRX85, SLITL2, Vasorin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vasn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- extracellular domain
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- TGFbeta binding
- EGF_CA
- transmembrane/cytoplasmic domain
- FN3
- Leucine rich repeat N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- colorectal cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- proliferation
- migration
- invasion by
- sensitivity
- response by
- sprouting angiogenesis by
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- Nucleus
- Mitochondria
- chromatin
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vasn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to redox state
- negative regulation of epithelial to mesenchymal transition
- cellular response to hypoxia
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- mitochondrion
- extracellular matrix
- lysosomal membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- protein binding
- cadherin binding