Tead3 Gene Summary [Mouse]
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Tead3 |
| Official Name | TEA domain family member 3 [Source:MGI Symbol;Acc:MGI:109241] |
| Ensembl ID | ENSMUSG00000002249 |
| Bio databases IDs | |
| Aliases | TEA domain family member 3 |
| Synonyms | DTEF-1, ETFR-1, LOC669027, Tcf13r2, TEAD5, TEA domain family member 3, TEA domain transcription factor 3, TEF-5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tead3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- YAP binding domain
- transcription factor binding
- protein binding
- TEA/ATTS domain
- transcription factor activity
- DNA binding
Pathways
Biological processes and signaling networks where the Tead3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplastic cell transformation
- insomnia
- febrile seizure
- flu
- metabolic syndrome X
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tead3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female pregnancy
- embryonic organ development
- hippo signaling cascade
- asymmetric neuroblast division
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity