Diaph3

Enables actin binding activity; microtubule binding activity; and protein homodimerization activity. Involved in actin filament polymerization. Acts upstream of or within several processes, including autophagosome-lysosome fusion; cytoskeleton organization; and myeloid cell differentiation. Located in cytoplasm and nucleus. Part of ESCRT I complex and filamentous actin. Is active in several cellular components, including cleavage furrow; cytoskeleton; and stereocilia tip-link density. Is expressed in several structures, including alimentary system; brain; gonad; submandibular gland primordium; and vibrissa. Used to study autosomal dominant auditory neuropathy 1 and congenital dyserythropoietic anemia. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1. Orthologous to human DIAPH3 (diaphanous related formin 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Diaph3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Diaph3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Diaph3 gene, providing context for its role in the cell.