Spout1 Gene Summary [Mouse]
Predicted to enable miRNA binding activity. Predicted to be involved in maintenance of centrosome location and miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in kinetochore; mitotic spindle; and spindle pole centrosome. Is expressed in embryo and extraembryonic component. Orthologous to human SPOUT1 (SPOUT domain containing methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Spout1 |
| Official Name | SPOUT domain containing methyltransferase 1 [Source:MGI Symbol;Acc:MGI:106544] |
| Ensembl ID | ENSMUSG00000039660 |
| Bio databases IDs | |
| Aliases | SPOUT domain containing methyltransferase 1 |
| Synonyms | 9930028P05, C9orf114, CENP-32, D2Wsu81e, HSPC109, SPOUT domain containing methyltransferase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spout1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Putative RNA methyltransferase
- SPOUT superfamily of SAM-dependent RNA methyltransferases
- rRNA (uridine) methyltransferase
- protein binding
- N-methyltransferase
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoli
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spout1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- posttranscriptional regulation of gene expression
- maintenance of centrosome location
- production of miRNAs involved in gene silencing by miRNA
- methylation
Cellular Component
Where in the cell the gene product is active
- spindle pole centrosome
- mitotic spindle
- cytoplasm
- kinetochore
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- protein binding
- RNA binding
- methyltransferase activity